What is 7-Keto-DHEA?

7-KETO DHEA is a naturally occurring metabolite derived from DHEA (Dehydroepiandrosterone). It can be found in many of our body tissues but cannot be converted to active androgens (testosterone) and estrogens. 7-KETO DHEA is more potent than other DHEA.

DHEA is a hormone whose decline with aging is believed to contribute to some age-associated conditions, including impairment of immune function. The decline in immune function that occurs in older individuals can predispose this population to increased susceptibility to infection and even cancer.

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Where does 7-Keto-DHEA come from?

7-oxo DHEA is a derivative of DHEA that also declines with age and has been demonstrated to promote T-cell function in human lymphocytes (a type of white blood cell). Of the three types of immune system response, T-cell, or cellular immunity is the one in which abnormalities have been most consistently found in older individuals. People with impaired cellular immunity frequently have a less than optimal response to flu vaccination, rendering the vaccine less beneficial.

Who needs it and what are some symptoms of deficiency?

As part of an exercise program, 7-KETO DHEA may improve lean body mass by reducing cortisol (a stress hormone that is immune suppressive and catabolic) and increasing testosterone-to-cortisol ratios enabling the body to build muscle in a growth promoting environment. 7-Keto DHEA has also been shown to increase thermogenesis, or your body's ability to burn calories. Give your training efforts a boost with this non-hormonal, non-androgenic derivative of DHEA.

How much should be taken? Are there side effects?

Dietary supplements such as 7-oxo DHEA may someday become widely used as immune system modulators, particularly as the older percentage of the population increases.